H6916

Macrophage Colony-Stimulating Factor human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• Sinônimo(s): MCSF
• Número MDL: MFCD00166591
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• product name: Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture
• fonte biológica: human
• Nível de qualidade: 100
• recombinante: expressed in HEK 293 cells
• Ensaio: ≥95% (SDS-PAGE)
• forma: lyophilized powder
• potência: ≤4 ng/mL EC₅₀
• qualidade: endotoxin tested
• peso molecular: dimer 35-40 kDa (glycosylated)
• embalagem: pkg of 10 μg
• fabricante/nome comercial: HumanZyme
• técnica(s): cell culture | mammalian: suitable
• nº de adesão UniProt: P09603
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... CSF1(1435)

Descrição

Descrição geral

M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.

Ações bioquímicas/fisiológicas

Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).

forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de análise

The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).

Citação

1. Mazur, E.M., and Cohen, J.L., Clin. Pharmacol. Ther., 46, 250 (1989).
2. Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3. Metcalf, D., Blood, 67, 257 (1986).
4. Mufson, R.A., et al., Cell. Immunol., 119, 182 (1989).
5. Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).

Informações legais

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable