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G0282

Sigma-Aldrich

Granulocyte-Macrophage Colony-Stimulating Factor from mouse

GM-CSF, from mouse, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

GM-CSF

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About This Item

Número MDL:
MFCD00241918
Código UNSPSC:
12352202
NACRES:
NA.77

fonte biológica

mouse

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥97% (SDS-PAGE)

forma

lyophilized powder

potência

≤0.2 ng/mL EC50 (corresponds to ≥5 × 106 units/mg)

qualidade

endotoxin tested

peso molecular

~15 kDa (125 amino acids including N-terminal methionine)

embalagem

pkg of 5 and 50 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤1 EU/mg

cor

white

solubilidade

water: soluble, clear, colorless

nº de adesão UniProt

P01587

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... CSF2(12981) , Csf2(12981)

Categorias relacionadas

Ações bioquímicas/fisiológicas

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.

forma física

Lyophilized from 10 mM acetic acid plus 250 μg BSA.

Nota de análise

The EC50 activity of mouse GM-CSF is tested in culture using murine FDP-1 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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M A Guthridge et al.
Stem cells (Dayton, Ohio), 16(5), 301-313 (1998-10-10)
The process of ligand binding leading to receptor activation is an ordered and sequential one. High-affinity binding of GM-CSF, interleukin 3 (IL-3), and IL-5 to their receptors induces a number of key events at the cell surface and within the
R C Skoda
Journal of receptor and signal transduction research, 19(1-4), 741-772 (1999-03-11)
The helical cytokines constitute a family of proteins with a common three-dimensional structure. They exert a wide variety of biological effects with a preference for the hematopoietic system. The effects of helical cytokines are mediated by cell surface receptors, which
A Kelso
Immunology and cell biology, 76(4), 300-317 (1998-09-02)
Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious tools and targets for strategies designed to promote, inhibit or redirect these responses. However, the complexity of the cytokine network has hindered
M H Heim
Journal of receptor and signal transduction research, 19(1-4), 75-120 (1999-03-11)
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and growth factors have been found to activate Jaks and STATs. Jaks (Janus Kinases) are a unique class
Bin Ji et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(47), 12255-12267 (2008-11-21)
We demonstrate the significance of peripheral benzodiazepine receptor (PBR) imaging in living mouse models of Alzheimer's disease (AD) as biomarkers and functional signatures of glial activation. By radiochemically and immunohistochemically analyzing murine models of the two pathological hallmarks of AD
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