G0792
Granulocyte-Macrophage Colony-Stimulating Factor from rat
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophililzed powder
Sinônimo(s):
GM-CSF
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About This Item
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Nome do produto
Granulocyte-Macrophage Colony-Stimulating Factor from rat, GM-CSF, recombinant, expressed in E. coli
fonte biológica
rat
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
>97% (SDS-PAGE)
Formulário
lyophilized powder
potência
0.03-0.1 ng/mL
qualidade
endotoxin tested
peso molecular
14.7 kDa
embalagem
pkg of 5X5 μg
pkg of 5 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
Impurezas
<1 EU/μg
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
rat ... CSF2(116630) , Csf2(116630)
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Ações bioquímicas/fisiológicas
Four distinct colony-stimulating factors (CSFs) promoting survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte-macrophage-CSF (GM-CSF), granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF), and interleukin-3 (IL-3, Multi-CSF). GM-CSF is a multipotential growth factor, stimulating proliferation of progenitor cells from more than one hematopoietic lineage (granulocyte, macrophage, and eosinophil). GM-CSF stimulates colony formation from pluripotent progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. GM-CSF induces myeloid progenitor cells from bone marrow to form colonies containing macrophages and granulocytes in a semisolid media. It is produced by various cell types (activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts) in response to cytokine and inflammatory stimuli. In addition to granulocyte-macrophage progenitors, GMCSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF can induce nonhematopoietic cells such as endothelial cells to migrate and proliferate. It also stimulates the proliferation of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines. GM-CSF exerts its biological effects through binding to specific cell surface receptors. The high affinity GM-CSF receptors contain a GM-CSF-specific α?chain and a common α ?chain.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.
Nota de preparo
Recombinant Rat Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is produced from a DNA sequence encoding mature rat GM-CSF. This recombinant protein is a mixture of two rat GM-CSFs, the 127 amino acid form and the 128 amino acid methionyl form. Mature rat GM-CSF has a calculated mass of 14.7 kDa. GM-CSF, an acidic glycoprotein, is species-specific.
Nota de análise
The biological activity is measured by its ability to induce proliferation of the factor-dependent mouse cell line, DA3.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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