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SML1893

Sigma-Aldrich

RO5256390

≥98% (HPLC)

Sinônimo(s):

(S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine

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About This Item

Fórmula empírica (Notação de Hill):
C13H18N2O
Número CAS:
1043495-96-0
Peso molecular:
218.29
Número MDL:
MFCD28405494
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

atividade óptica

[α]/D 14 to 19°, c = 1 in methanol

cor

white to beige

solubilidade

DMSO: 10 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC[C@@H](C[C@H]1COC(N)=N1)C2=CC=CC=C2

InChI

1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1

chave InChI

IXDKFUBXESWHSL-JQWIXIFHSA-N

Ações bioquímicas/fisiológicas

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaine′s reinforcng effects, and blocks binge-eating disorder.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Vincent M Lam et al.
European journal of pharmacology, 763(Pt B), 136-142 (2015-06-21)
Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. These compounds exert their effect by activating a class of G protein-coupled receptors termed Trace-Amine Associated Receptors (TAARs), where TAAR1 is the only
Antonio Ferragud et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(7), 1458-1470 (2016-11-03)
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of obesity and eating disorders, as well as of the recently proposed disorder of food addiction. Trace amine-associated receptor 1 (TAAR1) is a highly conserved G-protein-coupled
F G Revel et al.
Molecular psychiatry, 18(5), 543-556 (2012-05-30)
Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In

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