SML0198

Fenoldopam mesylate

≥98% (HPLC)

• Sinônimo(s): Fenoldopam methanesulfonate
• Fórmula empírica (Notação de Hill): C₁₆H₁₆ClNO₃ · CH₄O₃S
• Número CAS: 67227-57-0
• Peso molecular: 401.86
• Número CE: 266-612-7
• Número MDL: MFCD04112986
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825223
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white to tan
• pf: 271 °C (lit.)
• solubilidade: DMSO: ≥15 mg/mL at ~60 °C
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
• InChI: 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
• chave InChI: CVKUMNRCIJMVAR-UHFFFAOYSA-N
• Informações sobre genes: human ... DRD1(1812)

Descrição

Aplicação

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

Ações bioquímicas/fisiológicas

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.

Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

Características e benefícios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302 - H317 - H319
• Declarações de precaução: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable