P7791

Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Sinônimo(s): 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Fórmula empírica (Notação de Hill): C₁₉H₂₁N₅O₄ · HCl
• Número CAS: 19237-84-4
• Peso molecular: 419.86
• Beilstein: 4303561
• Número CE: 242-903-4
• Número MDL: MFCD00058177
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277793
• NACRES: NA.77

Propriedades

• product name: Prazosin hydrochloride, ≥99.0% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥99.0% (HPLC)
• forma: powder
• solubilidade: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• cadeia de caracteres SMILES: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• chave InChI: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Informações sobre genes: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descrição

Descrição geral

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Aplicação

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Ações bioquímicas/fisiológicas

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Características e benefícios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Atenção

Hygroscopic; light sensitive.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H336,H361fd,H373
• Declarações de precaução: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Classificações de perigo: Repr. 2 - STOT RE 2 - STOT SE 3
• Órgãos-alvo: Central nervous system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves