C7897

Clonidine hydrochloride

solid

• Sinônimo(s): 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
• Fórmula empírica (Notação de Hill): C₉H₉Cl₂N₃ · HCl
• Número CAS: 4205-91-8
• Peso molecular: 266.55
• Beilstein: 4163525
• Número CE: 224-121-5
• Número MDL: MFCD00036705
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277750
• NACRES: NA.77

Propriedades

• forma: solid
• Nível de qualidade: 100
• cor: white
• solubilidade: H₂O: soluble; methanol: soluble
• originador: Boehringer Ingelheim
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
• chave InChI: ZNIFSRGNXRYGHF-UHFFFAOYSA-N
• Informações sobre genes: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Descrição

Descrição geral

Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.

Aplicação

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:

• in ex vivo leptin release assay
• to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
• to study its influence on the sleep of larval zebrafish
• to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation

Clonidine hydrochloride has been used:

• to reduce central noradrenaline levels
• to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
• to attenuate thermal and mechanical pain hypersensitivity in rats
• as a positive control for pertussis toxin (PTX)

Ações bioquímicas/fisiológicas

α₂-adrenoceptor agonist; I₁ imidazoline binding site ligand.

Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.

Características e benefícios

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H330
• Declarações de precaução: P301 + P310 + P330 - P304 + P340 + P310
• Classificações de perigo: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges