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Documentos Principais

SML1006

Sigma-Aldrich

EGA

≥98% (HPLC)

Sinônimo(s):

2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

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About This Item

Fórmula empírica (Notação de Hill):
C16H16BrN3O
Número CAS:
415687-81-9
Peso molecular:
346.22
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 5 mg/vial, clear (warmed)

temperatura de armazenamento

2-8°C

Ações bioquímicas/fisiológicas

EGA is a small molecule that blocks the entry of anthrax lethal toxin by inhibiting trafficking pathways in acidified endosomes, without affecting endosome pH. EGA blocks trafficking of other toxins, including diphtheria toxin, but does not inhibit trafficking of ricin. The compound EGA attenuates lysosomal targeting and degradation of the EGF receptor, but does not block does not block endosomal recycling of transferrin.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
044M4757V

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Pitstop 2 ≥98% (HPLC)

Sigma-Aldrich

SML1169

Pitstop 2

Dynasore hydrate

Sigma-Aldrich

D7693

Dynasore hydrate

Toxina da difteria lyophilized powder, Product is in unnicked form

Sigma-Aldrich

D0564

Toxina da difteria

Cloroquina powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Cloroquina

Samuel J Dobson et al.
Antiviral research, 179, 104819-104819 (2020-05-12)
During virus entry, members of the Polyomaviridae transit the endolysosomal network en route to the endoplasmic reticulum (ER), from which degraded capsids escape into the cytoplasm and enter the nucleus. Emerging evidence suggests that viruses require both endosomal acidification and
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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