PZ0178

PHA 767491 hydrochloride

≥98% (HPLC)

• Sinônimo(s): 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride
• Fórmula empírica (Notação de Hill): C₁₂H₁₁N₃O · xHCl
• Número CAS: 845538-12-7
• Peso molecular: 213.24 (free base basis)
• Número MDL: MFCD11519962
• Código UNSPSC: 51111800
• ID de substância PubChem: 329823752
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: off-white to yellow
• solubilidade: H₂O: >25 mg/mL
• cadeia de caracteres SMILES: Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3
• InChI: 1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
• chave InChI: IMVNFURYBZMFDZ-UHFFFAOYSA-N

Descrição

Aplicação

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Ações bioquímicas/fisiológicas

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.

PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9.

PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable