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P4620

Sigma-Aldrich

PD 146176

≥98% (HPLC), solid

Sinônimo(s):

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

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About This Item

Fórmula empírica (Notação de Hill):
C15H11NS
Número CAS:
4079-26-9
Peso molecular:
237.32
Número MDL:
MFCD05664738
Código UNSPSC:
51111800
ID de substância PubChem:
24724579
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

cor

white to beige

solubilidade

DMSO: soluble >10 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

chave InChI

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Informações sobre genes

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Aplicação

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Ações bioquímicas/fisiológicas

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
067K4617V
067K46173V
067K46172
067K46171
067K4617

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Erastin ≥98% (HPLC)

Sigma-Aldrich

E7781

Erastin

Deferoxamine mesylate salt powder, ≥92.5% (TLC)

Sigma-Aldrich

D9533

Deferoxamine mesylate salt

Jiang Yang et al.
Scientific reports, 9(1), 13316-13316 (2019-09-19)
Ovarian cancer (OvCa), while accounting for only 3% of all women's cancer, is the fifth leading cause of cancer death among women. One of the most significant obstacles to successful OvCa treatment is chemoresistance. The current lack of understanding of
David M Tobin et al.
PloS one, 8(7), e67828-e67828 (2013-07-23)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here
Yoo Jin Na et al.
Cancers, 11(11) (2019-11-14)
Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase
Manuela Schneider et al.
Neoplasia (New York, N.Y.), 12(3), 254-263 (2010-03-18)
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and created
Haider H Dar et al.
The Journal of clinical investigation, 128(10), 4639-4653 (2018-09-11)
Ferroptosis is a death program executed via selective oxidation of arachidonic acid-phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic bacterium, Pseudomonas aeruginosa, that

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