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K3888

Sigma-Aldrich

Kenpaullone

≥98%

Sinônimo(s):

9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one, NSC 664704

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About This Item

Fórmula empírica (Notação de Hill):
C16H11BrN2O
Número CAS:
142273-20-9
Peso molecular:
327.18
Número MDL:
MFCD02683595
Código UNSPSC:
12352200
ID de substância PubChem:
24278507
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98%

Formulário

solid

cor

yellow

solubilidade

DMSO: 18 mg/mL, clear, yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI

1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)

chave InChI

QQUXFYAWXPMDOE-UHFFFAOYSA-N

Informações sobre genes

human ... CDC2(983)
mouse ... Gsk3b(56637)
rat ... Gsk3b(84027)

Aplicação

Kenpaullone has been used:
  • as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
  • as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
  • as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

Ações bioquímicas/fisiológicas

Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.

Características e benefícios

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Embalagem

Store under argon

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
076M4708V
072K4607

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