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N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

Sinônimo(s):

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

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About This Item

Fórmula empírica (Notação de Hill):
C13H18N2O5S
Número CAS:
123653-11-2
Peso molecular:
314.36
Número MDL:
MFCD00882995
Código UNSPSC:
12352200
ID de substância PubChem:
24897540
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

off-white

pf

127-128 °C

solubilidade

DMSO: >5 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

chave InChI

KTDZCOWXCWUPEO-UHFFFAOYSA-N

Informações sobre genes

human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743)
mouse ... Ptgs2(19225)

Aplicação

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:
  • the cardiac rate in zebrafish embryos
  • apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
  • the lipopolysaccharide (LPS) induced anorexia in rats

Ações bioquímicas/fisiológicas

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.
Selective cyclooxygenase-2 (COX-2) inhibitor.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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