A8674

Antimycin A from Streptomyces sp.

• Sinônimo(s): Antipiricullin
• Número CAS: 1397-94-0
• Número MDL: MFCD01779723
• Código UNSPSC: 12352200
• ID de substância PubChem: 24891355
• NACRES: NA.77

Propriedades

• forma: powder
• Nível de qualidade: 300
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
• InChI: 1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
• chave InChI: UIFFUZWRFRDZJC-RBVQMQRASA-N

Descrição

Descrição geral

Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation.

Chemical structure: peptide

Aplicação

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures
• in organello ATP production assay in Trypanosoma brucei cells
• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Ações bioquímicas/fisiológicas

Inhibitor of electron transfer at complex III. Induces apoptosis.

Qualidade

A mixture of antimycins.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H300,H400
• Declarações de precaução: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Classificações de perigo: Acute Tox. 2 Oral - Aquatic Acute 1
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges