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Documentos Principais

C0858

Sigma-Aldrich

Cyclooxygenase 2 human

≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein

Sinônimo(s):

COX-2, Prostaglandin H synthase 2

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About This Item

Número MDL:
MFCD00071378
Código UNSPSC:
12352204
NACRES:
NA.32

recombinante

expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells

Nível de qualidade

200

Ensaio

≥70% (SDS-PAGE)

Formulário

aqueous solution

atividade específica

≥8000 units/mg protein

peso molecular

dimer subunit mol wt 70-74 kDa

nº de adesão UniProt

P35354

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... PTGS2(5743)

Ações bioquímicas/fisiológicas

COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is the inducible form of cyclooxygenase, induced by phorbol esters, lipopolysaccharides, and cytokines. COX-2 is upregulated in the neovasculature of malignant tumors. Inhibition of COX-2 with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased tumor growth.

Outras notas

Tagged with a six-residue histidine sequence near the N-terminus.

Definição da unidade

One unit will consume 1.0 nanomole of oxygen per minute at pH 8 at 37 °C.

forma física

Solution in 80 mM Tris, pH 8.0, with 0.3 mM DDC, 0.01% TWEEN® 20 and 10% glycerol

Substratos

KM for arachidonate = 6.5 μM. Exhibits activity and sensitivity to NSAIDs similar to the non-tagged enzyme.

Informações legais

TWEEN is a registered trademark of Croda International PLC

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCK4738
SLBZ1423
SLBV9863
SLBV1459
SLBP5262V

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Hematin porcine

Sigma-Aldrich

H3281

Hematin porcine

3-Hydroxy-3-methylglutaryl-CoA reductase human solution

Sigma-Aldrich

H7039

3-Hydroxy-3-methylglutaryl-CoA reductase human

Lipoxidase from Glycine max (soybean) Type I-B, lyophilized powder, ≥50,000 units/mg solid

Sigma-Aldrich

L7395

Lipoxidase from Glycine max (soybean)

Prostaglandin I2 sodium salt ≥96% (HPLC), synthetic, powder

Sigma-Aldrich

P6188

Prostaglandin I2 sodium salt

María J Pérez et al.
Journal of food science, 83(5), 1454-1462 (2018-04-17)
This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This
Masanori Sugimoto et al.
Drug development research, 77(1), 20-28 (2016-01-15)
Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies were conducted to confirm human COX inhibition and absorption of
Alejandra Moreno et al.
Natural product communications, 10(6), 991-994 (2015-07-23)
Zuccagnia punctata Cav. (Fabaceae) is an Argentine medicinal aromatic shrub (jarilla pispito, puspus, lata and jarilla macho). The chalcones were identified as pigments responsible for the yellow color of the flowers. Hydroethanolic extracts were obtained both from fresh flowers and
Kaneez Fatima et al.
Frontiers in nutrition, 9, 857256-857256 (2022-04-26)
Carvacrol, a monoterpene known for its pharmacological activities, is present in the essential oil of Origanum majorana, Origanum vulgare, Thymus vulgaris, and Lippia graveolens. It is used in food as a flavoring and preservative agent in cosmetics and medicines because
Tetsuo Kida et al.
PloS one, 9(5), e96481-e96481 (2014-05-07)
To evaluate the pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) in the retinochoroidal tissues of rabbits. The cyclooxygenase (COX) inhibitory activity of diclofenac, bromfenac, and amfenac, an active metabolite of nepafenac, were determined using human-derived COX-1 and
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