H7039

3-Hydroxy-3-methylglutaryl-CoA reductase human

solution

• Sinônimo(s): HMGCoA Reductase, HMGR
• Número da licença da enzima: 1.1.1.34 (BRENDA, IUBMB)
• Código UNSPSC: 12352204
• NACRES: NA.54

Propriedades

• Ensaio: ≥90% (SDS-PAGE)
• Nível de qualidade: 200
• forma: solution
• atividade específica: 2-8 units/mg protein
• peso molecular: ~76 kDa (for the fusion protein)
• nº de adesão UniProt: P04035
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... HMGCR(3156)

Descrição

Aplicação

3-Hydroxy-3-methylglutaryl-CoA reductase human has been used:

• in anti-HMGCR enzyme linked immunosorbent assay (ELISA)
• as an antigen to measure anti-HMGCR antibodies by blot analysis
• in HMG-CoA reductase activity assays
• as an antigen to compare in-house antigen via sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)/western blot

Ações bioquímicas/fisiológicas

3-Hydroxy-3-methylglutaryl-CoA reductase/HMGCR serves as a rate limiting enzyme in mevalonate pathway. It also controls the oncogenic Hippo transducers TAZ/YAP. HMGCR also perform as a genetic modifier for Alzheimer′s disease (AD).

Hydroxy-3-methylglutaryl-CoA reductase catalyzes the committed step in cholesterol biosynthesis.

propriedades físicas

Consists of the HMG CoA reductase catalytic domain fused to GST protein.

Definição da unidade

One unit will convert 1.0 μmole of NADPH to NADP⁺ per minute at 37 °C.

forma física

Supplied as a solution containing 250 μg protein in 50 mM Tris pH 7.5, with 5 mM DTT, 1:200 Protease Inhibitor Cocktail (Catalog Number P8340) and 50% (w/v) glycerol.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable