H5914

N^α-Methylhistamine dihydrochloride

solid

• Sinônimo(s): N-Methyl-1H-imidazole-4-ethanamine dihydrochloride, NAMH dihydrochloride
• Fórmula empírica (Notação de Hill): C₆H₁₁N₃ · 2HCl
• Número CAS: 16503-22-3
• Peso molecular: 198.09
• Número MDL: MFCD00134838
• Código UNSPSC: 12352116
• ID de substância PubChem: 24724503
• NACRES: NA.77

Propriedades

• Formulário: solid
• Nível de qualidade: 100
• cor: white
• solubilidade: H₂O: >20 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].Cl[H].CNCCc1c[nH]cn1
• InChI: 1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
• chave InChI: AYUQICXJAMPXPF-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Nα-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis.

NAMH, which is produced in the gastric mucosa by H. pylori, is a potent H2R agonist as well as a H3R agonist.

Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC₅₀ concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.

Características e benefícios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Qualidade

The product is pure based on elemental analysis results, NMR and MS spectra.

Informações de segurança

• Pictogramas: GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H315,H318,H335
• Declarações de precaução: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves