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M4910

Sigma-Aldrich

1-Methylhistamine dihydrochloride

≥98% (TLC), powder

Sinônimo(s):

1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C6H11N3 · 2HCl
Número CAS:
6481-48-7
Peso molecular:
198.09
Número MDL:
MFCD00037000
Código UNSPSC:
12352204
ID de substância PubChem:
24277805
NACRES:
NA.32

Nome do produto

1-Methylhistamine dihydrochloride, ≥98% (TLC), powder

Nível de qualidade

200

Ensaio

≥98% (TLC)

Formulário

powder

solubilidade

water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl[H].Cl[H].Cn1cnc(CCN)c1

InChI

1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H

chave InChI

AGXVEALMQHTMSW-UHFFFAOYSA-N

Informações sobre genes

human ... HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340)

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Aplicação

1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

Ações bioquímicas/fisiológicas

1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.
Major metabolite of histamine by histamine N-methyltransferase.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
119M4037V
13181152
036M4080V
036M4081V
13151008

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Sigma-Aldrich

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Supelco

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Histamine dihydrochloride ≥99% (TLC), powder

Sigma-Aldrich

H7250

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L-(+)-Tartaric acid ACS reagent, ≥99.5%

Sigma-Aldrich

251380

L-(+)-Tartaric acid

Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
Koro Gotoh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(9), 1131-1133 (2005-05-17)
Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior.
Mouhammad Motawaj et al.
Journal of Alzheimer's disease : JAD, 22(3), 861-871 (2010-09-23)
Neuropathological studies have reported a strong neurofibrillary degeneration of the tuberomamillary nucleus, the region of origin of histamine neurons, in Alzheimer's disease (AD). Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of
F Gbahou et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 945-954 (2010-06-10)
We previously suggested that therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). However, H(3)Rs exhibit constitutive activity, and most H(3)R antagonists act as inverse agonists. Here, we have investigated the effects
Yves Dauvilliers et al.
Sleep, 35(10), 1359-1366 (2012-10-02)
To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. sensitive liquid
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