H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• Sinônimo(s): 2-(4-Imidazolyl)ethylamine
• Fórmula empírica (Notação de Hill): C₅H₉N₃
• Número CAS: 51-45-6
• Peso molecular: 111.15
• Beilstein: 2012
• Número CE: 200-100-6
• Número MDL: MFCD00005210
• Código UNSPSC: 12352116
• eCl@ss: 32160406
• ID de substância PubChem: 24895783
• NACRES: NA.77

Propriedades

• product name: Histamine, ≥97.0%
• Ensaio: ≥97.0%
• pb: 167 °C/0.8 mmHg (lit.)
• pf: 83-84 °C (lit.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• chave InChI: NTYJJOPFIAHURM-UHFFFAOYSA-N
• Informações sobre genes: human ... CA1(759) , CA2(760) , HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340) ; rat ... Hrh1(24448) , Hrh3(85268)

Descrição

Descrição geral

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Aplicação

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Ações bioquímicas/fisiológicas

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H315,H317,H319,H334,H335
• Declarações de precaução: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves