53300

Histamine dihydrochloride

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

• Sinônimo(s): 2-(4-Imidazolyl)ethylamine dihydrochloride
• Fórmula empírica (Notação de Hill): C₅H₉N₃ · 2HCl
• Número CAS: 56-92-8
• Peso molecular: 184.07
• Beilstein: 3624116
• Número CE: 200-298-4
• Número MDL: MFCD00012703
• Código UNSPSC: 12352116
• eCl@ss: 32160406
• ID de substância PubChem: 329757931
• NACRES: NA.77

Propriedades

• Nome do produto: Histamine dihydrochloride, ≥99.0% (AT)
• Ensaio: ≥99.0% (AT)
• Formulário: powder or crystals
• resíduo de ignição: ≤0.2%
• perda: ≤0.2% loss on drying, 20 °C (HV)
• pf: 244-247 °C; 249-252 °C (lit.)
• solubilidade: H₂O: 0.1 g/mL, clear, colorless
• traços de ânion: sulfate (SO₄^2-): ≤200 ppm
• traços de cátion: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• cadeia de caracteres SMILES: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
• chave InChI: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Informações sobre genes: human ... HRH1(3269)

Descrição

Descrição geral

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

Ações bioquímicas/fisiológicas

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

Outras notas

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H315,H317,H319,H334,H335
• Declarações de precaução: P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves