P5780

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

• Sinônimo(s): 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
• Fórmula linear: NH₂(CH₂)₄NH₂ · 2HCl
• Número CAS: 333-93-7
• Peso molecular: 161.07
• Beilstein: 3906680
• Número CE: 206-375-9
• Número MDL: MFCD00012526
• Código UNSPSC: 12352207
• ID de substância PubChem: 24898707
• NACRES: NA.75

Propriedades

• fonte biológica: microbial; synthetic
• Nível de qualidade: 200
• linha de produto: BioReagent
• Ensaio: ≥97% (TLC)
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• pf: 280 °C (dec.) (lit.)
• solubilidade: H₂O: 100 mg/mL
• cadeia de caracteres SMILES: Cl[H].Cl[H].NCCCCN
• InChI: 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
• chave InChI: XXWCODXIQWIHQN-UHFFFAOYSA-N

Descrição

Descrição geral

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Aplicação

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

Ações bioquímicas/fisiológicas

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.

Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.

Informações de segurança

• Pictogramas: GHS06,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H302,H311,H314,H330
• Declarações de precaução: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 1
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves