P8783

Progesterone

powder, BioReagent, suitable for cell culture

• Sinônimo(s): 4-Pregnene-3,20-dione
• Fórmula empírica (Notação de Hill): C₂₁H₃₀O₂
• Número CAS: 57-83-0
• Peso molecular: 314.46
• Beilstein: 1915950
• Número CE: 200-350-6
• Número MDL: MFCD00003658
• Código UNSPSC: 12352209
• ID de substância PubChem: 24898978
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• descrição: synthesized from materials derived from plant source
• linha de produto: BioReagent
• Ensaio: ≥99%
• forma: powder
• potência: 0.1-20 ng/mL
• técnica(s): cell culture | mammalian: suitable
• pf: 128-132 °C (lit.)
• solubilidade: absolute ethanol: 1 mg/mL
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• chave InChI: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Informações sobre genes: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Descrição

Descrição geral

Progesterone is a steroid hormone secreted by the ovaries.

Aplicação

Progesterone has been used:

• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Ações bioquímicas/fisiológicas

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Outras notas

Steroid hormone produced by the corpus luteum.

forma física

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstituição

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H351,H360FD,H362
• Declarações de precaução: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classificações de perigo: Carc. 2 - Lact. - Repr. 1A
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges