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F9911

Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

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About This Item

Código UNSPSC:
12352202
eCl@ss:
42020141
NACRES:
NA.75

fonte biológica

human plasma

Nível de qualidade

200

Ensaio

>90% (SDS-PAGE)

Formulário

lyophilized powder

peso molecular

30 kDa

embalagem

pkg of 0.5 mg

técnica(s)

cell culture | mammalian: suitable

Impurezas

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

solubilidade

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

nº de adesão UniProt

P02751

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Informações sobre genes

human ... FN1(2335)

Descrição geral

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Aplicação

Fibronectin proteolytic fragment has been used in solid phase binding assay.

Ações bioquímicas/fisiológicas

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Atenção

The product should be stored at -20°C.

Nota de preparo

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

recomendado

Nº do produto
Descrição
Preços

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
069M4158V
11181147
068M4107V
11180231
037M4175V

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S Huff et al.
The Journal of biological chemistry, 269(22), 15563-15570 (1994-06-03)
The N-terminal 29-kDa fragment of fibronectin (Fn29K) contains five type I "finger" modules. It binds to heparin, fibrin, and bacteria and is involved in fibronectin (Fn) matrix assembly. Binding to Staphylococcus aureus involves a cell wall-associated protein that contains approximately
Fibronectin in Health and Disease (2018)
Maryada Sharma et al.
PloS one, 8(7), e69343-e69343 (2013-08-13)
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ. Fibronectin (Fn) is an essential component of the ECM, and plays
E Nègre et al.
The Journal of biological chemistry, 269(35), 22039-22045 (1994-09-02)
A 30-kDa proteolytic fragment from the gelatin/collagen-binding domain of fibronectin is a potent inhibitor of fibronectin binding to Candida albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin
Ming Liu et al.
Scientific reports, 5, 14449-14449 (2015-09-25)
Bacterial adhesins play a pivotal role in the tight bacteria-host cells attachment to initiate the downstream processes and bacterial infection of hosts. In this study, we identified a novel adhesin, VpadF in V. parahaemolyticus. Deletion of VpadF in V. parahaemolyticus
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Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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