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F0287

Sigma-Aldrich

Fibronectina

lyophilized powder, 70 kDa

Sinônimo(s):

Fibronectin

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About This Item

Número MDL:
MFCD00131062
Código UNSPSC:
12352202
eCl@ss:
42020141
NACRES:
NA.75

fonte biológica

human plasma

Nível de qualidade

200

Ensaio

>90% (SDS-PAGE)

forma

lyophilized powder

peso molecular

70 kDa

embalagem

pkg of 0.5 mg

técnica(s)

cell culture | mammalian: suitable

Impurezas

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

solubilidade

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

nº de adesão UniProt

P02751

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Informações sobre genes

human ... FN1(2335)

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Descrição geral

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Aplicação

Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

Ações bioquímicas/fisiológicas

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Atenção

The product should be stored at -20°C.

Nota de preparo

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
Fibronectin in Health and Disease (2018)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
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mBio, 12(5), e0106221-e0106221 (2021-10-20)
While Staphylococcus aureus has classically been considered an extracellular pathogen, these bacteria are also capable of being taken up by host cells, including nonprofessional phagocytes such as endothelial cells, epithelial cells, or osteoblasts. The intracellular S. aureus lifestyle contributes to
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Artigos

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

Protocolos

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs at sigmaaldrich.com

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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