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E0251

Sigma-Aldrich

Estrone 3-sulfate sodium salt

contains ~35% Tris as stabilizer

Sinônimo(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Fórmula linear:
C18H21O5SNa
Número CAS:
438-67-5
Peso molecular:
372.41
Número MDL:
MFCD00070035
Código UNSPSC:
12352202
ID de substância PubChem:
24894364
NACRES:
NA.77

fonte biológica

synthetic (organic)

Nível de qualidade

200

esterilidade

non-sterile

Ensaio

≥98% (TLC)

Formulário

powder

contém

~35% Tris as stabilizer

técnica(s)

inhibition assay: suitable

solubilidade

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

Condições de expedição

ambient

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

chave InChI

GQZNDBBLTDOIBE-DLEHHZMWSA-N

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Embalagem

Package size based on steroid content

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H351,H360,H362

Classificações de perigo

Carc. 2 - Lact. - Repr. 1A

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
086M4083V
085M4170V
099M4044V
13181143
088M4146V

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Sigma-Aldrich

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Sigma-Aldrich

E2127

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p-Aminohippuric acid ≥99%

Sigma-Aldrich

A1422

p-Aminohippuric acid

Benzbromarone analytical standard

Supelco

B5774

Benzbromarone

Thiocholesterol

Sigma-Aldrich

136115

Thiocholesterol

Pyrimethamine VETRANAL®, analytical standard

Supelco

46706

Pyrimethamine

E S M Silva et al.
Theriogenology, 86(7), 1749-1756 (2016-08-09)
The present study evaluated the influence of different regimens of estradiol benzoate (EB) treatments followed by a single dose of long-acting progesterone (LA P4) on plasma estrogen and P4 concentrations in noncyclic mares prepared as embryo recipients. Twenty-one anestrous mares
Christopher A Pearl et al.
Domestic animal endocrinology, 33(4), 451-459 (2006-10-13)
The steroid hormone regulation of the epididymis in a high estrogen producing animal like the boar is not currently understood. To test the hypothesis that the boar epididymis is an estrogen and androgen responsive tissue, the presence of estrogen and
Takashi Nozawa et al.
Pharmaceutical research, 22(10), 1634-1641 (2005-09-24)
The aim of the study is to suppress the progress of estrogen-dependent breast cancer by inhibiting the membrane transporter, which mediates the internalization of estrone-3-sulfate as estrogen precursor in the cancer cells. The uptake of estrone-3-sulfate by estrogen-dependent breast cancer
Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
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