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E9145

Sigma-Aldrich

Estrone 3-sulfate potassium salt

≥98%

Sinônimo(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Fórmula linear:
C18H21O5SK
Número CAS:
1240-04-6
Peso molecular:
388.52
Número CE:
214-985-1
Número MDL:
MFCD00056410
Código UNSPSC:
51111800
ID de substância PubChem:
24894691
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥98%

forma

powder

contém

~35% Tris as stabilizer

cor

off-white to light tan

solubilidade

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

Condições de expedição

ambient

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[K].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.K.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

chave InChI

XFQXTMKDDYWSBS-DLEHHZMWSA-N

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Ações bioquímicas/fisiológicas

The most abundant estrogen in adult human circulation. Conversion to estradiol requires steroid sulfatase activity. This activity was used to evaluate freshly resected bone fragments against cultured osteoblasts and osteosearcoma cells as models for studying human bone metabolism.

Embalagem

Package size based on steroid content

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H319,H335,H361

Declarações de precaução

P201 - P305 + P351 + P338 - P308 + P313

Classificações de perigo

Eye Irrit. 2 - Repr. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Sigma-Aldrich

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p-Aminohippuric acid ≥99%

Sigma-Aldrich

A1422

p-Aminohippuric acid

Equilin

Sigma-Aldrich

E8126

Equilin

Estriol ≥97%

Sigma-Aldrich

E1253

Estriol

Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
L M M C Sousa et al.
Placenta, 33(10), 788-794 (2012-07-31)
Our objectives were to investigate the possible role of VEGFA in bovine placenta steroid synthesis and to determine whether cloned derived placental cells present similar responses as non-cloned ones. Placental cells from cloned (term) and non-cloned (days 90, 150, 210
Elizabeth J Folkerd et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(24), 2977-2980 (2012-07-18)
To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer. Recent studies have
Anne Mette Lund Würtz et al.
Cancer causes & control : CCC, 23(10), 1711-1720 (2012-08-29)
Levels of endogenous estrogen and SHBG are associated with risk of breast cancer among women who have never used hormone replacement therapy (HRT). We investigated these associations in both never and baseline users of HRT. A nested case-control study was
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