E9505

β-Estradiol 3-sulfate sodium salt

≥93%

• Sinônimo(s): 1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
• Fórmula linear: C₁₈H₂₃O₅SNa
• Número CAS: 4999-79-5
• Peso molecular: 374.43
• Número MDL: MFCD00056553
• Código UNSPSC: 51111800
• ID de substância PubChem: 24894699
• NACRES: NA.77

Propriedades

• esterilidade: non-sterile
• Nível de qualidade: 200
• Ensaio: ≥93%
• Formulário: powder
• contém: ~70% N-methyl-D-glucamine as stabilizer
• solubilidade: methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Condições de expedição: ambient
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: [Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
• InChI: 1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
• chave InChI: PYPVMTJYMKHIST-LBARCDFESA-N

Descrição

Descrição geral

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Aplicação

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Ações bioquímicas/fisiológicas

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Embalagem

Package size based on steroid content

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302 + H332,H351
• Declarações de precaução: P202 - P261 - P264 - P301 + P312 - P304 + P340 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges