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B5774

Supelco

Benzbromarone

analytical standard

Sinônimo(s):

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran

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About This Item

Fórmula empírica (Notação de Hill):
C17H12Br2O3
Número CAS:
3562-84-3
Peso molecular:
424.08
Número CE:
222-630-7
Número MDL:
MFCD00078962
Código UNSPSC:
41116107
ID de substância PubChem:
329773266
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

200

Ensaio

~95%

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3

InChI

1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

chave InChI

WHQCHUCQKNIQEC-UHFFFAOYSA-N

Informações sobre genes

human ... CYP2C19(1557) , CYP2C9(1559) , SLC22A12(116085)

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Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCK5558
SLBZ8912
038F0014

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

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Ácido úrico ≥99%, crystalline

Sigma-Aldrich

U2625

Ácido úrico

Phloretin ≥99%

Sigma-Aldrich

P7912

Phloretin

Uric acid sodium salt

Sigma-Aldrich

U2875

Uric acid sodium salt

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) powder

Sigma-Aldrich

D3669

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)

Quinidine anhydrous

Sigma-Aldrich

Q3625

Quinidine

Acetaminofeno meets USP testing specifications, 98.0-102.0%, powder

Sigma-Aldrich

A5000

Acetaminofeno

Tip W Loo et al.
Biochemistry, 50(21), 4393-4395 (2011-04-28)
Deletion of Phe508 from the first nucleotide-binding domain of the CFTR chloride channel causes cystic fibrosis because it inhibits protein folding. Indirect approaches such as incubation at low temperatures can partially rescue ΔF508 CFTR, but the protein is unstable at
Atsushi Iwamura et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(5), 838-846 (2011-02-16)
Drug-induced hepatotoxicity is a major problem in drug development, and reactive metabolites generated by cytochrome P450s are suggested to be one of the causes. CYP2C9 is one of the major enzymes in hepatic drug metabolism. In the present study, we
Fernanda Cristina Mazali et al.
Nephron. Experimental nephrology, 120(1), e12-e19 (2011-12-01)
Hyperuricemia frequently complicates cyclosporine (CsA) therapy. Previous studies have shown that hyperuricemia exacerbates interstitial and vascular lesions in the cyclosporine model. We tested the hypothesis that normalization of uric acid could prevent the development of cyclosporine toxicity. CsA nephropathy was
Tip W Loo et al.
Biochemical pharmacology, 83(3), 345-354 (2011-12-06)
The most common cause of cystic fibrosis is deletion of Phe508 in the first nucleotide-binding domain (NBD) of the CFTR chloride channel, which inhibits protein folding. ΔF508 CFTR can be rescued by indirect approaches such as low temperature but the
Kaoru Kobayashi et al.
Biopharmaceutics & drug disposition, 33(8), 466-473 (2012-08-31)
Benzbromarone (BBR) is metabolized to 1'-hydroxy BBR and 6-hydroxy BBR in the liver. 6-Hydroxy BBR is further metabolized to 5,6-dihydroxy BBR. The aim of this study was to identify the CYP isozymes involved in the metabolism of BBR to 1'-hydroxy
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