D6134
2-desoxi-D-glicose
≥99% (GC), crystalline
Sinônimo(s):
2-desoxi-D-arabino-hexose
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About This Item
Fórmula empírica (Notação de Hill):
C6H12O5
Número CAS:
Peso molecular:
164.16
Beilstein:
1723331
Número CE:
Número MDL:
Código UNSPSC:
12352201
ID de substância PubChem:
NACRES:
NA.25
Produtos recomendados
fonte biológica
synthetic (organic)
Ensaio
≥99% (GC)
Formulário
crystalline
técnica(s)
gas chromatography (GC): suitable
cor
white
pf
146-147 °C (lit.)
solubilidade
H2O: soluble 330 mg/mL, clear, colorless
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI
1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
chave InChI
VRYALKFFQXWPIH-PBXRRBTRSA-N
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Aplicação
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Ações bioquímicas/fisiológicas
A 2-desoxi-D-glicose (2-desoxiglicose) é um análogo de glicose que inibe a glicólise através de suas ações sobre a hexoquinase, a etapa que limita a taxa da glicólise. É fosforilada pela hexoquinase em 2-DG-P, que não pode ser mais metabolizada pela fosfoglicose isomerase. Isso leva ao acúmulo de 2-DG-P na célula e ao esgotamento do ATP celular. In vitro, a 2-desoxiglicose demonstrou induzir a autofagia, aumentar a produção de ROS e ativar a AMPK.
Nota de preparo
A further purification of the Grade II material by recrystallization.
Outras notas
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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