A9210
Annexin V FITC Conjugate from human placenta
Sinônimo(s):
Annexin V, Calphosbindin I, Lipocortin V, PAP-1
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About This Item
Código UNSPSC:
41106305
NACRES:
NA.32
Produtos recomendados
forma
buffered aqueous solution
Nível de qualidade
Extensão da rotulagem
1-2 mol FITC per mol annexin V
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
Informações sobre genes
human ... ANXA5(308)
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Aplicação
For detection of apoptotic cells by flow cytometry or fluorescence microscopy.
Ações bioquímicas/fisiológicas
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.
Embalagem
Package size based on protein content
forma física
Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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