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Key Documents

PHR1611

Supelco

Mercaptopurine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

6-Mercaptopurine monohydrate, 6-Purinethiol, 6-Thiohypoxanthine

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About This Item

Fórmula empírica (Notação de Hill):
C5H4N4S·H2O
Número CAS:
Peso molecular:
170.19
Beilstein:
4012091
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to BP 773
traceable to USP 1392002

família API

mercaptopurine

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 1 g

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O.S=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

chave InChI

WFFQYWAAEWLHJC-UHFFFAOYSA-N

Informações sobre genes

human ... PPAT(5471)

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mercaptopurine is an anticancer and an immunosuppressive drug employed for the management of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn′s disease, etc. Its mode of action involves interference in the nucleic acid synthesis by the inhibition of purine metabolism.

Aplicação

Mercaptopurine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, suspensions, and double drug liposomes by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3476 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Skull and crossbonesHealth hazard

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3


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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF MERCAPTOPURINE-AN ANTI CANCER DRUG IN PHARMACEUTICAL FORMULATIONS
Suman P, et al.
European Journal of Biomedical AND Pharmaceutical sciences, 5(5), 752-759 (2018)
Effect of buffer and antioxidant on stability of a mercaptopurine suspension
Aliabadi HM, et al.
American Journal of Health-System Pharmacy, 65(5), 441-447 (2008)
6-mercaptopurine and daunorubicin double drug liposomes?preparation, drug-drug interaction and characterization
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