PHR1437

Temozolomida

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): 3,4-Di-hidro-3-metil-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazina-8-carboxamida, 3-Metil-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazina-carboxamida, 4-Metil-5-oxo-2,3,4,6,8-pentazabiciclo[4.3.0]nona-2,7,9-trieno-9-carboxamida, 8-Carbamoil-3-metilimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-ona, NSC 362856
• Fórmula empírica (Notação de Hill): C₆H₆N₆O₂
• Número CAS: 85622-93-1
• Peso molecular: 194.15
• Número MDL: MFCD00866492
• Código UNSPSC: 41116107
• ID de substância PubChem: 329822600
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to USP 1643543
• família API: temozolomide
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 1 g
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN1N=Nc2c(ncn2C1=O)C(N)=O
• InChI: 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
• chave InChI: BPEGJWRSRHCHSN-UHFFFAOYSA-N

Descrição

Descrição geral

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Temozolomide is an alkylating agent of the imidazotetrazine group. It is a chemotherapy drug, used in the treatment of anaplastic astrocytoma, glioblastoma multiforme and malignant metastatic melanoma, which works by arresting cancer cell growth.

Aplicação

Temozolomide may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by reverse phase liquid chromatography and UV spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA2745 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H315,H319,H335,H340,H350,H360FD
• Declarações de precaução: P202 - P261 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3