P4394

cis-Diammineplatinum(II) dichloride

≥99.99% (trace metal analysis), crystalline, macrophage activator

• Sinônimo(s): cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Fórmula linear: Pt(NH₃)₂Cl₂
• Número CAS: 15663-27-1
• Peso molecular: 300.05
• Número CE: 239-733-8
• Número MDL: MFCD00011623
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278632
• NACRES: NA.77

Propriedades

• Nome do produto: cis-Diammineplatinum(II) dichloride, crystalline
• Formulário: crystalline
• cor: yellow
• pf: 270 °C (lit.)
• espectro de atividade do antibiótico: neoplastics
• Modo de ação: DNA synthesis | interferes
• originador: Corden
• cadeia de caracteres SMILES: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• chave InChI: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Descrição

Aplicação

cis-Diammineplatinum(II) dichloride has been used:

• in cell viability measurement in cochlear explants
• in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
• in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Ações bioquímicas/fisiológicas

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Armazenamento e estabilidade

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300,H315,H317,H319,H334,H335,H350
• Declarações de precaução: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable