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Documentos Principais

PHR1011

Supelco

Ethylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Ethyl 4-hydroxybenzoate, EP, Ethylparaben

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About This Item

Fórmula linear:
HOC6H4CO2C2H5
Número CAS:
Peso molecular:
166.17
Beilstein:
1101972
Número CE:
Número MDL:
Código UNSPSC:
41116107
eCl@ss:
39024522
ID de substância PubChem:
Número E:
E214
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. E2425000
traceable to USP 1267000

família API

parabens

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

p.e.

297-298 °C (lit.)

pf

114-117 °C (lit.)

aplicação(ões)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCOC(=O)c1ccc(O)cc1

InChI

1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3

chave InChI

NUVBSKCKDOMJSU-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Ethylparaben may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3158 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC
Shabir GA.
Journal of Pharmaceutical and Biomedical Analysis, 34(1), 207-213 (2004)
Maw-Rong Lee et al.
Journal of chromatography. A, 1120(1-2), 244-251 (2006-03-04)
This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography-mass spectrometry (LC-MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol (alpha-t) and alpha-tocopherol acetate (alpha-ta)
Suzanne Abbas et al.
Drug metabolism and pharmacokinetics, 25(6), 568-577 (2010-10-12)
Parabens (alkyl esters of 4-hydroxybenzoic acid) are widely used as preservatives in drugs, cosmetic products, and foodstuffs. Safety concerns have recently increased due to the potential health risks associated to exposure to large amounts of these substances. Biotransformation of parabens
Sawsan El Hussein et al.
Experimental dermatology, 16(10), 830-836 (2007-09-12)
Concern is continuously raised about the safety of parabens which are present in most of the cosmetic preparations. In this investigation, methyl-, ethyl-, propyl- and butyl paraben (MP, EP, PP, BP), in a commercial cosmetic lotion, were deposited on human
S Nicoli et al.
Journal of pharmaceutical sciences, 97(11), 4830-4839 (2008-03-05)
This work aims at investigating the nicotinamide (NA)-ethyl-paraben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64

Protocolos

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

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