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Documentos Principais

PHR1022

Supelco

Butylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

4-Hydroxybenzoic acid butyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C11H14O3
Número CAS:
Peso molecular:
194.23
Beilstein:
1103741
Número CE:
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. B1217000
traceable to USP 1084000

família API

parabens

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-30°C

InChI

1S/C11H14O3/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7,12H,2-3,8H2,1H3

chave InChI

QFOHBWFCKVYLES-UHFFFAOYSA-N

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Descrição geral

Butylparaben is a compound, which belongs to the class of parabens.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Butylparaben may be used as a reference standard for the determination of the analyte in cosmetics, food samples and human breast cancerous tissue by chromatography techniques.
Butylparaben may be used as an internal standard in the analysis of aspirin and warfarin in pharmaceutical formulations using reversed-phase high performance liquid chromatography (RP-HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB7759 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Corrosion

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Eye Dam. 1 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Certificados de análise (COA)

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GC-MS method for the determination of paraben preservatives in the human breast cancerous tissue.
Shanmugam G, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 96(2), 391-396 (2010)
Development and validation of a reversed-phase liquid chromatographic method for analysis of aspirin and warfarin in a combination tablet formulation
Montgomery RE, et al.
Journal of Pharmaceutical and Biomedical Analysis, 15, 73-82 (1996)
Effects of butylparaben on the male reproductive system in rats
Oishi S
Toxicology and Industrial Health, 17, 31-39 (2001)
Anna Viridén et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 99-110 (2010-11-18)
This study investigates the effect of the chemical heterogeneity of hydroxypropyl methylcellulose (HPMC) on the release of model drug substances from hydrophilic matrix tablets. The hypothesis was that the release of drug substances could be influenced by possible interactions with
Anuschka Liekens et al.
Journal of chromatography. A, 1218(38), 6654-6662 (2011-08-25)
The effect of the addition of 25%, 50% and 75% (weight percent, wt%) of larger particles (resp. 3 and 5 μm) to a commercial batch of 1.9 μm particles has been investigated as an academic exercise to study the effects

Protocolos

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

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