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61739

Sigma-Aldrich

N-Lauroylsarcosine

purum p.a., ≥98.0% (GC)

Sinônimo(s):

N-Dodecanoyl-N-methylglycine, Sarkosyl L

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About This Item

Fórmula linear:
CH3(CH2)10CON(CH3)CH2COOH
Número CAS:
97-78-9
Peso molecular:
271.40
Beilstein:
1792084
Número CE:
202-608-3
Número MDL:
MFCD00021749
Código UNSPSC:
12352100
ID de substância PubChem:
57651861
NACRES:
NA.21

descrição

anionic

Nível de qualidade

200

grau

purum p.a.

Ensaio

≥98.0% (GC)

peso molecular

271.40 g/mol

técnica(s)

protein quantification: suitable

Impurezas

≤0.2% water

resíduo de ignição

≤0.1%

pf

45-50 °C

traços de ânion

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

traços de cátion

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤20 mg/kg

grupo funcional

amide
carboxylic acid

cadeia de caracteres SMILES

CCCCCCCCCCCC(=O)N(C)CC(O)=O

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

chave InChI

BACYUWVYYTXETD-UHFFFAOYSA-N

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Descrição geral

N-Lauroylsarcosine (N-Dodecanoyl-N-methylglycine, Sarkosyl L, LS) is an anionic surfactant. Its microbicidal action against herpes simplex type 2 (HSV-2) intravaginal infection in a murine model has been investigated.

Aplicação

N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin†

Pictogramas

Skull and crossbonesCorrosion
GHS06,GHS05

Palavra indicadora

Danger

Frases de perigo

H315,H318,H330

Classificações de perigo

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCG8849
BCCG5961
BCCG6616
BCCG6241
BCCG0145

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Tiocianato de guanidina ≥97% (titration)

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Desoxicolato de sódio

SAFC

S1827

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Zwittergent® 3-14 Detergent Synthetic zwitterionic detergent, which unlike other amphoteric surfactants, retains its zwitterionic character over a wide pH range.

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Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Kunie Ando et al.
The American journal of pathology, 178(2), 803-816 (2011-02-02)
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a
Yoshiaki Furukawa et al.
The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)
The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here
S Roy et al.
Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)
The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS
Jian Sun et al.
Nucleic acids research, 43(14), 6827-6846 (2015-07-04)
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation
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