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G6639

Sigma-Aldrich

Tiocianato de guanidina

≥97% (titration)

Sinônimo(s):

Rodanida de guanidínio, Tiocianato de guanidínio

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About This Item

Fórmula linear:
NH2C(=NH)NH2 · HSCN
Número CAS:
593-84-0
Peso molecular:
118.16
Beilstein:
3563461
Número CE:
209-812-1
Número MDL:
MFCD00013027
Código UNSPSC:
12352209
ID de substância PubChem:
24895264
NACRES:
NA.55

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥97% (titration)

forma

powder or crystals

técnica(s)

RNA extraction: suitable

cor

white to off-white

pf

120-122 °C (lit.)

solubilidade

water: 4 M, clear, colorless

traços de ânion

chloride (Cl-): ≤2.5%

cadeia de caracteres SMILES

SC#N.NC(N)=N

InChI

1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

chave InChI

ZJYYHGLJYGJLLN-UHFFFAOYSA-N

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Aplicação

Guanidine thiocyanate has been used:
  • as a denaturing agent to study its effects on surface activity of globular protein
  • for the extraction of total RNA from primary hepatocytes
  • as a component of the incubating buffer for extraction of DNA from human bone
  • as a component of the guanidine thiocyanate (GITC) lysis buffer for extraction of elephant shark DNA
  • as a component of lysis solution for extraction of RNA from rat pancreatic tissues
Agente caotrópico e forte desnaturante; solubiliza células.

Ações bioquímicas/fisiológicas

Guanidine thiocyanate (GTC) is a powerful protein denaturant and can denature endogenous ribonucleases. It plays a role in separation of ribosomal ribonucleic acid (rRNA) from ribosomes. GTC in combination with phenol and chloroform can be used in isolation of total RNA from cells and tissues.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1C

Perigos de suplementos

EUH032

Código de classe de armazenamento

8B - Non-combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
WXBD9013V
WXBD6866V
WXBD4795V
BCCG2183
BCCG2184

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Emilia Bramanti et al.
Analytical biochemistry, 351(1), 100-113 (2006-01-28)
In this article, a multidimensional dynamic surface tension detector (DSTD), in a parallel configuration with a UV-visible diode array absorbance detector, is presented in a novel flow injection analysis (FIA) application to study the effects of chemical denaturants urea, guanidinium
Julian R Peat et al.
F1000Research, 6, 526-526 (2017-06-06)
Methylation of CG dinucleotides constitutes a critical system of epigenetic memory in bony vertebrates, where it modulates gene expression and suppresses transposon activity. The genomes of studied vertebrates are pervasively hypermethylated, with the exception of regulatory elements such as transcription
Nicolas Chuvin et al.
Cellular and molecular gastroenterology and hepatology, 4(2), 263-282 (2017-07-29)
Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ activates the canonical SMAD pathway through its interaction with the serine/threonine kinase type I and II
Kai Y Mak et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(9), 1434-1443 (2015-05-23)
Angiotensin converting enzyme 2 (ACE2) which breaks down profibrotic peptide angiotensin II to antifibrotic peptide angiotensin-(1-7) is a potential therapeutic target in liver fibrosis. We therefore investigated the long-term therapeutic effect of recombinant ACE2 using a liver-specific adeno-associated viral genome
Yuji Suzuki et al.
Bioscience, biotechnology, and biochemistry, 72(7), 1951-1953 (2008-07-08)
High-quality total RNA was extracted using a cethyltrimethylammonium bromide-containing buffer followed by an acid guanidium thiocyanate-phenol-chloroform treatment from recalcitrant plant tissues such as tree leaves (pine, Norway spruce, ginkgo, Japanese cedar, rose), flowers (rose, Lotus japonicus) and storage tissues (seeds
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