516705

o-Phenanthroline

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.

• Sinônimo(s): o-Phenanthroline, 1,10-Phenanthroline Monohydrate
• Fórmula empírica (Notação de Hill): C₁₂H₈N₂ · xH₂O
• Número CAS: 5144-89-8
• Peso molecular: 180.21 (anhydrous basis)
• Número MDL: MFCD00149973
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (titration)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white to cream
• solubilidade: DMSO: 100 mg/mL; ethanol: 25 mg/mL; water: 3 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• InChI: 1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
• chave InChI: PPQJCISYYXZCAE-UHFFFAOYSA-N

Descrição

Descrição geral

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe²⁺ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Metalloprotease inhibitor

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Toxic (F)

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Stix, B., et al. 2001. Am. J. Pathol.159, 561.
Bolzan, A.D., et al. 2000. Mutat. Res.447, 221.
Wang, Y., et al. 1999. J. Biol. Chem.274, 33043.
Harayama, T., et al. 1999. Jpn. J. Can. Res.90, 942.
Krane, S.M., et al. 1996. J. Biol. Chem.271, 28509.
Uhm, J.H., et al. 1996. Clin. Exp. Metastasis14, 421.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301,H410
• Declarações de precaução: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable