P9375

1,10-Phenanthroline monohydrate

reagent grade

• Sinônimo(s): o-Phenanthroline monohydrate
• Fórmula empírica (Notação de Hill): C₁₂H₈N₂ · H₂O
• Número CAS: 5144-89-8
• Peso molecular: 198.22
• Beilstein: 4008096
• Número CE: 200-629-2
• Número MDL: MFCD00149973
• Código UNSPSC: 12352116
• ID de substância PubChem: 24278663
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• grau: reagent grade
• forma: powder
• pf: 100-104 °C (lit.)
• solubilidade: methanol: 200 mM (Stock solution is stable for months at –20° C.)
• cadeia de caracteres SMILES: O.c1cnc2c(c1)ccc3cccnc23
• InChI: 1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
• chave InChI: PPQJCISYYXZCAE-UHFFFAOYSA-N
• Informações sobre genes: human ... FNTA(2339)

Descrição

Descrição geral

Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.

Aplicação

1,10-Phenanthroline monohydrate has been used:

• as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
• as a negative control in in situ zymography of mice heart samples
• in in vitro resveratrol chelation and reducing activities assays to chelate iron

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.

Ações bioquímicas/fisiológicas

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301,H410
• Declarações de precaução: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges