B8385

Bestatin hydrochloride

powder, ≥98% (HPLC)

• Sinônimo(s): N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₆H₂₄N₂O₄ · HCl
• Número CAS: 65391-42-6
• Peso molecular: 344.83
• Beilstein: 4628066
• Número MDL: MFCD00058004
• Código UNSPSC: 12352202
• ID de substância PubChem: 24278278
• NACRES: NA.77

Propriedades

• Nome do produto: Bestatin hydrochloride, ≥98% (HPLC)
• fonte biológica: synthetic (organic)
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• pf: 216 °C
• solubilidade: water: 25 mg/mL, clear to very slightly hazy, colorless
• espectro de atividade do antibiótico: neoplastics
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
• InChI: 1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
• chave InChI: XGDFITZJGKUSDK-UDYGKFQRSA-N

Descrição

Descrição geral

Chemical structure: amino acid derivatives

Ações bioquímicas/fisiológicas

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

Nota de preparo

Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)