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Merck
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Documentos Principais

437627

Sigma-Aldrich

Lipopolysaccharide, E. coli O111: B4

from E. coli, , lyophilized, iNOS stimulator, Calbiochem®

Sinônimo(s):

E. coli Lipopolysaccharide, E. coli O111:B4 LPS

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About This Item

Código UNSPSC:
12352201
NACRES:
NA.77

Nome do produto

Lipopolysaccharide, E. coli O111: B4, Lipopolysaccharide, E. coli O111: B4 stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes

Nível de qualidade

descrição

RTECS - OJ0895400

Formulário

lyophilized

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

Impurezas

≤2.0% Protein
≤2.5% nucleic acid

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

Descrição geral

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxic shock, a profound life-threatening consequence of sepsis. More recently, these bacterial products have generated intense interest due to their pluropotential immunostimulatory activity as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cell activation by lipopolysaccharides produces a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor, and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
Inducible nitric oxide synthase
Product does not compete with ATP.
Reversible: no

Advertência

Toxicity: Harmful (C)

Nota de preparo

To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.

Reconstituição

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Outras notas

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.
Jackson, S.K., et al. 1992. Biochim. Biophys. Acta1135, 165.
O′Sullivan, M.G., et al. 1992. J. Biol. Chem.267, 14547.
Watanabe, K., et al. 1992. J. Cell. Physiol.150, 433.
Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med.38, 417.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration, occurs in sepsis. The goal of

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