L6529
Lipopolissacarídeos
γ-irradiated, BioXtra, suitable for cell culture
Sinônimo(s):
LPS
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About This Item
Produtos recomendados
fonte biológica
Escherichia coli (O55:B5)
Nível de qualidade
esterilidade
γ-irradiated
linha de produto
BioXtra
forma
lyophilized powder
purificado por
gel-filtration chromatography
técnica(s)
cell culture | mammalian: suitable
Impurezas
<3% Protein (Lowry)
solubilidade
H2O: 5 mg/mL, faintly hazy to hazy
temperatura de armazenamento
2-8°C
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Descrição geral
Lipopolysaccharides (LPS) are complex glycolipids that contain several components. Enterobacteriaceae, such as E. coli, have highly conserved lipid A linked to the antigenic O-polysaccharide. Hydrophobic lipid A forms the outer most component that plays a role in the biological properties attributed to endotoxic LPS. A short core oligosaccharide (core OS) is found to be attached to lipid A. Enterobacteria contain an antigenic, repeat-structure O-polysaccharide (O-PS) attached to the distal core OS to form smooth LPS. O-PS in E. coli contains ∼170 distinct antigens that interact with the host immune system. Based on the core OS structures in E. coli, they have been designated K-12 and R1 to R4.
Aplicação
LPS (lipopolysaccharide) from Escherichia coli 055:B5 has been used:
- to stimulate human PBMC to secrete cytokine.
- to stimulate wild type embryonic fibroblasts and mutants for the induction of phosphorylation of p56
- in the measurement of tumor necrosis factor-α levels and nuclear factor-κB p65 activities after stimulation
- in the stimulation of hamster lymphocytes in vitro
- to induce activated dendritic morphology in murine macrophage cell line in a study
Os lipopolissacarídeos (LPSs) são componentes característicos da parede celular de bactérias gram negativas. Os LPS e sua porção lipídica A estimulam as células do sistema imunológico inato através do receptor do tipo Toll 4 (TLR4), um membro da família de proteínas do receptor do tipo Toll 4 que reconhece patógenos comuns associados a padrões moleculares (PAMPs).
Ações bioquímicas/fisiológicas
LPS (lipopolysaccharide) is a major constituent of the outer membrane of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. The LPS confers antigenic and endotoxic characters to the bacteria. They are also important in resistance to infection by phages.
Reconstituição
Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.
Outras notas
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Nº do produto
Descrição
Preços
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 2 Oral
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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