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Key Documents

L3024

Sigma-Aldrich

Lipopolissacarídeos

purified by ion-exchange chromatography, TLR ligand tested

Sinônimo(s):

LPS

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About This Item

Número CE:
297-473-0
Número MDL:
MFCD00164401
Código UNSPSC:
12352201
NACRES:
NA.25

fonte biológica

Escherichia coli (O111:B4)

Nível de qualidade

200

forma

lyophilized powder

purificado por

ion-exchange chromatography

Impurezas

<1% Protein
<1% RNA

cor

white to yellow cast

solubilidade

water: soluble

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

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Descrição geral

This product is extracted from E. coli serotype O111:B4 and purified by ion exchange. The source strain is from a private collection. This LPS serotype has been used to stimulate B-cells and induce NOS in human hepatocytes.

Aplicação

Os lipopolissacarídeos (LPSs) são componentes característicos da parede celular de bactérias gram negativas. Os LPS e sua porção lipídica A estimulam as células do sistema imunológico inato através do receptor do tipo Toll 4 (TLR4), um membro da família de proteínas do receptor do tipo Toll 4 que reconhece patógenos comuns associados a padrões moleculares (PAMPs).

Ações bioquímicas/fisiológicas

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Nota de preparo

The product is soluble in water (5 mg/mL) or cell culture medium (1 mg/mL) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/mL) has been achieved in aqueous saline after vortexing and warming to 70-80 °C. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Outras notas

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Yoshitomo Hayama et al.
Journal of immunology (Baltimore, Md. : 1950), 200(11), 3790-3800 (2018-04-25)
Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid-activated mechanistic target of rapamycin complex 1 (mTORC1), is critical for the
Carl-Fredrik Johnzon et al.
Frontiers in immunology, 9, 1487-1487 (2018-07-11)
Mastitis is an inflammatory condition of the mammary tissue and represents a major problem for the dairy industry worldwide. The present study was undertaken to study how experimentally induced acute bovine mastitis affects inflammatory parameters and changes in the metabolome.
Sharon Elazar et al.
Veterinary research, 41(1), 10-10 (2009-10-16)
Mastitis, inflammation of the mammary tissue, is a common disease in dairy animals and mammary pathogenic Escherichia coli (MPEC) is a leading cause of the disease. Lipopolysaccharide (LPS) is an important virulence factor of MPEC and inoculation of the mammary
F T Silvestre et al.
Journal of dairy science, 94(5), 2285-2301 (2011-04-29)
The objectives were to evaluate the effects of differential supplementation of Ca salts (CS) of fatty acids (FA) on plasma acute phase proteins and both FA composition and function (i.e., activity and cytokine production) of neutrophils, during the peripartum and
Simon N Willis et al.
Nature communications, 8(1), 1426-1426 (2017-11-12)
Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family transcription factors regulate many aspects of haematopoiesis, although their functions in humoral immunity are difficult to decipher as a
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Conteúdo relacionado

Lipopolysaccharides

Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is localized in the outer layer of the membrane and is, in noncapsulated strains, exposed on the cell surface.

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