189725
Avidin, Egg White
Sinônimo(s):
Avidin, Egg White
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About This Item
Produtos recomendados
forma
lyophilized solid
Nível de qualidade
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
cor
white
solubilidade
dilute buffer: 5 mg/mL
distilled water: 5 mg/mL
Condições de expedição
ambient
temperatura de armazenamento
−20°C
Descrição geral
Avidin is a tetrameric glycoprotein and an anti-nutrient found in the eggs of all oviparous vertebrates. It constitutes 0.05–0.5% of the total protein in hen eggs. Avidin structure contains eight orthogonal antiparallel β-strands, a single disulfide bond, and a carbohydrate side chain.
Aplicação
Avidin, Egg White has been used as a blocking agent in protein-binding assays. It has also been used to form avidin-biotin linkage to conjugate gemcitabine onto microbubbles for drug delivery to in vivo model.
Ações bioquímicas/fisiológicas
Avidin can be used as a label for antibodies, fluorescent dyes, proteins,, and other molecules of interest to biochemists. The high binding affinity of avidin to biotin (vitamin H) causes the unavailability of biotin to microorganisms, which leads to the inhibition of their proliferation. This feature of avidin contributes to its antimicrobial property and affects biotin absorption in the body, resulting in vitamin B7 deficiency.
Advertência
Toxicity: Standard Handling (A)
Definição da unidade
One unit is defined as the amount of avidin that will bind 1 µg D-biotin at pH 8.9.
Reconstituição
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Avoid freeze/thaw cycles.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Visualizing structural changes of egg avidin to thermal and electric field stresses by molecular dynamics simulation
Zhu Y, et al.
LWT--Food Science and Technology, 151, 112139-112139 (2021)
Eva Krkavcová et al.
Biology open, 7(4) (2018-03-16)
Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We tested
Mu A et al.
Nature cell biology, 21(5), 592-602 (2019-04-10)
Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal segmental glomerulosclerosis, a kidney disease, and Charcot-Marie-Tooth disease, a neuropathy. All of the disease
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