T0167

D-(+)-Trealose

from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

• Sinônimo(s): α,α-Trealose, α-D-glicopiranosil-α-D-glicopiranosídeo
• Fórmula empírica (Notação de Hill): C₁₂H₂₂O₁₁ · 2H₂O
• Número CAS: 6138-23-4
• Peso molecular: 378.33
• Beilstein: 5322018
• Número CE: 202-739-6
• Número MDL: MFCD00071594
• Código UNSPSC: 12352201
• ID de substância PubChem: 24899871
• NACRES: NA.75

Propriedades

• Nível de qualidade: 200
• fonte biológica: Saccharomyces cerevisiae
• linha de produto: BioReagent
• Ensaio: ≥99%
• forma: powder
• técnica(s): cell culture | insect: suitable; cell culture | mammalian: suitable
• solubilidade: H₂O: 50 mg/mL
• cadeia de caracteres SMILES: [H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• chave InChI: DPVHGFAJLZWDOC-PVXXTIHASA-N

Descrição

Descrição geral

Trehalose is a non-reducing disaccharide, ubiquitously present in nature. It is used as a food preservative and also to retain enzymes, vaccines, cells and many other molecules. Trehalose is present as hemolymph sugar among the invertebrates.

Aplicação

D-(+)-Trehalose dihydrate has been used in a slow-freezing method for freezing rabbit oocytes. It has also been used in solid-surface vitrification (SSV) of in vitro-matured oocytes. It is suitable for use as a cryoprotectant in a variety of cell freezing media.

Ações bioquímicas/fisiológicas

Trehalose is essential for embryogenesis, carbon metabolism, photosynthesis and flowering in plants. It predominantly exists among the species that supports anhydrobiosis (life without water). It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions, such as heat, cold, dehydration, desiccation and oxidation. Trehalose acts as a chemical chaperone affecting protein folding. It is known to prevent amyloid generation and accummulation of β-amyloid in vitro. A similar effect of trehalose has been observed with huntingtin protein aggregation. Thus, it might serve as a protective agent in Alzheimer′s disease and Huntington′s disease.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)