857130P

18:1 Lyso PA

Avanti Research^™ - A Croda Brand

• Sinônimo(s): oleoyl lysophosphatidic acid; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/0:0); 18:1 LPA; o-LPA; 110681
• Fórmula empírica (Notação de Hill): C₂₁H₄₀O₇PNa
• Número CAS: 325465-93-8
• Peso molecular: 458.50
• Código UNSPSC: 51191904
• NACRES: NA.25

Propriedades

• descrição: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
• Ensaio: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• forma: powder
• embalagem: pkg of 1 × 1 g (857130P-1g); pkg of 2 × 100 mg (857130P-200mg); pkg of 1 × 25 mg (857130P-25mg)
• fabricante/nome comercial: Avanti Research^™ - A Croda Brand
• tipo de lipídio: cardiolipins; phospholipids
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);/q;+1/p-1/b10-9-;/t20-;/m1./s1
• chave InChI: XGRLSUFHELJJAB-JGSYTFBMSA-M

Descrição

Descrição geral

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, which has a glycerol backbone attached through a phosphate group, an aliphatic chain and a hydroxyl group. The phosphate group is linked to the sn-3 position and the aliphatic chain is linked to either sn-1 or sn-2 position. The hydroxyl group is connected to the remaining sn-1 or sn-2 position.

Aplicação

18:1 Lyso PA or 1-oleoyl-2-hydroxy-sn-glycero-3-phosphate has been used: to study its effects on intracellular calcium concentration [Ca²⁺]i transient in pheochromocytoma cell 12 (PC12) cells and primary astrocytes. It has also been used to study its effects on blood glucose level and physical endurance in fasted mice.

Ações bioquímicas/fisiológicas

Biological responses to LPA: Cell Proliferation, Inhibition of differentiation (neuroblastoma cells, myoblasts), Platelet aggregation, Smooth muscle contraction, Neurotransmitter release, Stress fibre formation/cell rounding/neurite retraction, Cell-surface-fibronectin binding, Tumor cell invasion, Chemotaxis (dictyostelium amoebae), Cl--mediated membrane depolarization (fibroblasts), Inhibition of connexin 43 based cell-cell communication, Increased tight junction permeability (brain endothelial cells). Note: The bioactivity of LPA appears to require long (i.e., C16 to C18) acyl carbon chains of the type usually found associated with membrane lipids although optimum requirements for a single type of acyl carbon chain are not universal. The bioactivity decreases with shorter chain length. In serum, oleoyl and palmitoyl fatty acid containing LPA are the predominant species.

Embalagem

5 mL Clear Glass Sealed Ampule (857130P-200mg)

5 mL Clear Glass Sealed Ampule (857130P-25mg)

60 mL Amber Wide Mouth Screw Cap Glass Bottle (857130P-1g)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3