L7260

Oleoyl-L-α-lysophosphatidic acid sodium salt

≥98%, solid

• Sinônimo(s): 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt, LPA sodium salt
• Fórmula empírica (Notação de Hill): C₂₁H₄₁O₇P · xNa⁺
• Número CAS: 22556-62-3
• Peso molecular: 436.52 (free acid basis)
• Número MDL: MFCD00133427
• Código UNSPSC: 12352211
• ID de substância PubChem: 24896456
• NACRES: NA.77

Propriedades

• Ensaio: ≥98%
• forma: solid
• cor: white
• tipo de lipídio: phosphoglycerides
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);;/b10-9+;;
• chave InChI: CHJOEWDRTPWOCY-TTWKNDKESA-N

Descrição

Descrição geral

Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.

Aplicação

Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:

• for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell line
• in RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assay
• in vitro luciferase assay and live-cell imaging

Ações bioquímicas/fisiológicas

Endogenous agonist for LPA₁ and LPA₂ receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

Características e benefícios

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Hygroscopic, photosensitive

Nota de preparo

Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)