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700060P

Avanti

desmosterol

Avanti Research™ - A Croda Brand

Sinônimo(s):

24-dehydrocholesterol; 5,24-cholestadien-3β-ol; 110798

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About This Item

Fórmula empírica (Notação de Hill):
C27H44O
Número CAS:
313-04-2
Peso molecular:
384.64
Código UNSPSC:
12352211
NACRES:
NA.25

descrição

3β-hydroxy-5,24-cholestadiene

Ensaio

>99% (TLC)

forma

powder

embalagem

pkg of 1 × 10 mg (700060P-10mg)
pkg of 1 × 5 mg (700060P-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

chave InChI

AVSXSVCZWQODGV-DPAQBDIFSA-N

Categorias relacionadas

Descrição geral

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

Aplicação

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

Ações bioquímicas/fisiológicas

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

Embalagem

5 mL Amber Glass Screw Cap Vial (700060P-10mg)
5 mL Amber Glass Screw Cap Vial (700060P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

geralmente comprado junto com este produto

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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cholestanol Avanti Research™ - A Croda Brand

Avanti

700064P

cholestanol

7-Dehydrocholesterol ≥95.0% (HPLC)

Sigma-Aldrich

30800

7-Dehydrocholesterol

dihydrolanosterol Avanti Research™ - A Croda Brand

Avanti

700067P

dihydrolanosterol

Triparanol ≥97% (HPLC), powder

Sigma-Aldrich

T5200

Triparanol

vibrant-m

P2920000

Pregnenolone isobutyrate

campesterol Avanti Research™ - A Croda Brand 700126P, powder

Avanti

700126P

campesterol

5α-Cholestan-3β-ol ≥95%

Sigma-Aldrich

D6128

5α-Cholestan-3β-ol

Campesterol ~65%

Sigma-Aldrich

C5157

Campesterol

Stearic acid Grade I, ≥98.5% (capillary GC)

Sigma-Aldrich

S4751

Stearic acid

María de Las Mercedes Carro et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183357-183357 (2020-05-18)
Ram sperm are particularly sensitive to freeze-thawing mainly due to their lipid composition, limiting their use in artificial insemination programs. We evaluated the extent of cholesterol and desmosterol incorporation into ram sperm through incubation with increasing concentrations of methyl-β-cyclodextrin (MβCD)-sterol
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of
Guangtao Li et al.
Journal of lipid research, 61(5), 758-766 (2020-01-23)
The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting

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