Pular para o conteúdo
Merck
Todas as fotos(3)

Documentos Principais

Visualizar Toda a Documentação

763896

Sigma-Aldrich

DL-α-Tocopherol methoxypolyethylene glycol succinate

greener alternative

Sinônimo(s):

Polyethylene glycol, TPGS-750-M

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(3)

About This Item

Número CAS:
1309573-60-1
Código UNSPSC:
51171641
NACRES:
NA.22

Formulário

powder

Nível de qualidade

100

adequação da reação

reagent type: catalyst
reaction type: C-H Activation
reagent type: surfactant

características do produto alternativo mais ecológico

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

temperatura de transição

Tm 29-34

categoria alternativa mais ecológica

, Aligned

Categorias relacionadas

Descrição geral

Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product TPGS-750-M is a lead surfactant for many transition metal-catalyzed cross-couplings and has been enhanced for catalytic efficiency. Find details here.

Aplicação

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors
DL-α-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M), a biodegradable and water-soluble derivative of natural vitamin E, is used as an environmentally benign nonionic surfactant in metal-catalyzed cross-coupling reactions in water. It is used in Heck, Suzuki-Miyaura, Sonogashira, and Negishi like couplings reactions. It can also be utilized in aminations, C-H activations, and olefin metathesis reactions.
TPGS-750-M can also be employed in:
  • The nucleophilic aromatic substitution reaction of aryl and heteroaryl halides with nitrogen, oxygen, and sulfur nucleophiles under mild conditions.
  • The preparation of quinoxaline-2,3 diones from quinoxalinones via C(sp2)-H hydroxylation reaction.
  • The intramolecular N-arylation of amines using a copper catalyst.

Outras notas

Watch Professor Lipshutz talk about TPGS-750-M in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

produto relacionado

Nº do produto
Descrição
Preços

902292

EvanPhos, ≥95%

907014

Coolade

909793

Coolade solution, 2 wt. % in H2O

911151

PS-750-M

911178

PS-750-M, solution, 3 wt. % in H2O

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BGBC2944V
BGBC1326V
MKBL1236
BGBB8197

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 4

1 of 4

(±)-α-Tocopherol phosphate disodium salt water-soluble α-tocopherol analog

Sigma-Aldrich

T2020

(±)-α-Tocopherol phosphate disodium salt

D-α-Tocopherol succinate semisynthetic, 1210 IU/g

Sigma-Aldrich

T3126

D-α-Tocopherol succinate

Poly(ethylene glycol) methyl ether average Mn 750

Sigma-Aldrich

202495

Poly(ethylene glycol) methyl ether

QuadraPure® TU macroporous, 400-600 μm particle size

Sigma-Aldrich

655422

QuadraPure® TU

TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature
Lipshutz BH, et al.
The Journal of Organic Chemistry, 76(11), 4379-4391 (2011)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
advanced synthesis and catalysis, 361(24), 5721-5726 (2019)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
Advanced Synthesis & Catalysis, 361(24), 5721-5726 (2019)
Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water
Kumar A and Bishnoi AK
Royal Society of Chemistry Advances, 5(26), 20516-20520 (2015)

Artigos

TPGS-750-M: Second-Generation Amphiphile for Organometallic Chemistry in Water at Room Temperature

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Nok – Third-Generation Amphiphile for Cross-Coupling Chemistry in Water

Micellular catalysis has provided the ability to carry out several commonly used transformations used in the synthetic community to be carried out in water.

Procedures for Transition-Metal-Catalyzed Cross-Coupling Reactions in Water at Room Temperature using TPGS-750-M

TPGS-750-M, a second generation surfactant, is useful for room temperature, palladium and ruthenium-catalyzed reactions in water. Reactions include the Heck reaction, Suzuki-Miyaura reaction, Sonogashira reaction, Buchwald-Hartwig amination reaction, Negishi reaction, and olefin metathesis.

Protocolos

Buchwald-Hartwig Amination Reaction in Water at Room Temperature using TPGS-750-M

Buchwald-Hartwig Amination Reaction in Water at Room Temperature using TPGS-750-M

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica