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691399

Sigma-Aldrich

Chlorosulfonyl isocyanate

Arxada quality, 99.0-100.3 % (w/w) (T)

Sinônimo(s):

N-Carbonylsulfamyl chloride, CSI

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About This Item

Fórmula linear:
ClSO2NCO
Número CAS:
1189-71-5
Peso molecular:
141.53
Beilstein:
1237247
Número CE:
214-715-2
Número MDL:
MFCD00011608
Código UNSPSC:
12352100
ID de substância PubChem:
329761405
NACRES:
NA.22

pressão de vapor

5.57 psi ( 20 °C)

Nível de qualidade

100

Formulário

liquid

qualidade

Arxada quality

fabricante/nome comercial

Arxada AG

concentração

99.0-100.3 % (w/w) (T)

Impurezas

≤1.00% chloropropylsulfonyl isocyanate

índice de refração

n20/D 1.447 (lit.)

p.e.

107 °C (lit.)

pf

−44 °C (lit.)

densidade

1.626 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

ClS(=O)(=O)N=C=O

InChI

1S/CClNO3S/c2-7(5,6)3-1-4

chave InChI

WRJWRGBVPUUDLA-UHFFFAOYSA-N

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Categorias relacionadas

Aplicação

  • Pharmaceutical intermediates: A study explored the synthesis and carbonic anhydrase inhibitory properties of sulfamides derived from Chlorosulfonyl isocyanate, demonstrating its potential in the development of new therapeutic agents, particularly for treating conditions involving carbonic anhydrase enzymes (Aksu et al., 2013).
  • Stereochemical synthesis applications: Chlorosulfonyl isocyanate was utilized for the stereoselective amination of chiral benzylic ethers in the total synthesis of (+)-sertraline, showcasing its critical role in the precise construction of complex pharmaceuticals (Lee et al., 2011).
  • One-pot synthetic transformations: The compound′s use in one-pot conversion of trimethylsilyl ethers into urethanes was highlighted, further applied to synthesize novel neuromodulators like carisbamate. This illustrates Chlorosulfonyl isocyanate′s versatility in facilitating efficient and innovative synthetic routes in medicinal chemistry (Dong et al., 2008).

Palavra indicadora

Danger

Frases de perigo

H302,H314,H317,H334

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Perigos de suplementos

EUH014

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

>230.0 °F

Ponto de fulgor (°C)

> 110 °C

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análise (COA)

Lot/Batch Number
BCCF1749
BCCF8168
BCCD7751
BCCC2738
BCBR4126V

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C P Sharma et al.
Biomaterials, medical devices, and artificial organs, 12(3-4), 215-233 (1984-01-01)
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded polyelectrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity.
G Crassous et al.
Biomaterials, 5(3), 153-156 (1984-05-01)
In this paper we report the preparation of a new asymmetric semipermeable styrene-isoprene-styrene block-copolymer membrane. Its modification by addition of gaseous N-chlorosulphonylisocyanate alters neither its permselectivity nor its water permeability rate. This modified membrane possesses an antithrombic activity which depends
J A Picard et al.
Journal of medicinal chemistry, 39(6), 1243-1252 (1996-03-15)
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro, with several compounds having IC50 values < 1 microM.

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