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64046

Sigma-Aldrich

2,3-Dimercapto-1-propanol

≥98% (iodometric)

Sinônimo(s):

BAL, British anti-Lewisite, DMP, Dimercaprol, Dithioglycerol

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About This Item

Fórmula linear:
HOCH2CH(SH)CH2SH
Número CAS:
59-52-9
Peso molecular:
124.23
Beilstein:
1732058
Número CE:
200-433-7
Número MDL:
MFCD00004864
Código UNSPSC:
12352100
ID de substância PubChem:
57651969
NACRES:
NA.22

Ensaio

≥98% (iodometric)

índice de refração

n20/D 1.572-1.574
n20/D 1.573 (lit.)

pb

120 °C/15 mmHg (lit.)

densidade

1.239 g/mL at 25 °C (lit.)

grupo funcional

hydroxyl

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OCC(S)CS

InChI

1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

chave InChI

WQABCVAJNWAXTE-UHFFFAOYSA-N

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Descrição geral

Dimercapto-1-propanol acts as a chelating agent and forms stable complexes with certain heavy metals, including arsenic, mercury, and lead.

Aplicação

2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H315,H319,H335

Classificações de perigo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

233.6 °F - closed cup

Ponto de fulgor (°C)

112 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análise (COA)

Lot/Batch Number
STBK5151
STBK1300
STBJ6932
STBJ4026
STBH9953

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S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
R Vos et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2736-2748 (2014-11-15)
Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
Megan O'Reilly et al.
American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 wk of gestation, the challenge of promoting lung growth
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(5), 713-720 (2014-11-22)
Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined
Do Hyun Kim et al.
Drug design, development and therapy, 11, 827-836 (2017-03-30)
The authors designed and synthesized 17 (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives to find a new chemical scaffold, showing excellent tyrosinase-inhibitory activity. Their tyrosinase-inhibitory activities were evaluated against mushroom tyrosinase at 50 μM, and five of the PDTM derivatives (PDTM3, PDTM7-PDTM9
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